CDX Cell Lines
Cell line-derived xenograft models (CDX models) are in vivo models where human-derived tumor cells are transplanted into the subcutis of mice for efficacy evaluation or tumor-related research; It is one of the most frequently used in vivo models for preclinical analyses of anticancer medicines.
GemPharmatech's extensive selection of CDX cell lines, including pancreatic cancer, breast cancer, colon cancer, lung cancer, and lymphoma, can accommodate the requirements of various pharmacodynamic and efficacy investigations. On top of this wide selection, GemPharmatech has engineered 32 CDX cell lines with luciferase to enable non-invasive tumor volume analysis using bioluminescence.
| Cancer Type | Unmodified Cell Line | Luciferase-Tagged Cell Line |
| Ademocarcimoma | Calu-3, NCI-H1666, NCI-H441,NCI-H1650 | |
| Acute Myeloid Leukemia | MOLM13, OCIAML3 | |
| Anaplastic Carcinoma | Calu-6 | |
| Barett Adenocarcinoma | OE33 | |
| Bladder Cancer | UM-UC-3, HT1376, RT4, T24, RT112/84 | |
| Brain Cancer | U251, U-87 MG | |
| Breast Cancer | BT-20, BT-474, BT-549, HCC1937, HCC1954, HCC1569, Hs 578T, JIMT-1, MCF7, MDA-MB-175VII, MDA-MB-231, MDA-MB-436, MDA-MB-453, MDA-MB-468, SK-BR-3, HCC70, T47D | MDA-MB-468-Luc, MDA-MB-231-Luc, MCF-Luc |
| Chondrosarcoma | SW1353 | |
| Clear Cell Carcinoma | Es-2 | |
| Colorectal Cancer | Colo205, HCT-116, HT29, HT-55, LoVo, LS174T, RKO, SW48 | |
| Colorectal Cancer; Dukes' Type C | Ls1034 | |
| Colorectal Cancer; Dukes' Type C, Grade III | SW948 | |
| Colorectal Cancer; Dukes' Type B | SW480 | |
| Colon Cancer | HT-29-Luc, HCT116-Luc, RKO-Luc | |
| Colon Adenocarcinoma | COLO-320 | |
| Duodenal Cancer | HuTu 80 | |
| Endometrial Carcinoma | HEC-1-A | |
| Esophagus | KYSE-150 | |
| Gastric Cancer | Hs 746T, MKN45, NCI-N87, SGC-7901, SNU-16, KATOIII, NUGC4 | |
| Glioblastoma | U251-Luc, U87 MG-Luc | |
| Leukemia | HL-60, Jurkat, K562, MOLT-4, MV-4-11, Nalm-6, SUP-B15, THP-1, CCRF-CEM, Hut78, TF1, Hs 505.T | Nalm6-Luc, K562-Luc, MOLM 13-Luc, HL60-Luc, MV-4-11-Luc, Jurkat-Luc |
| Liver Cancer | HepG2, Huh7 | Huh7-Luc, HepG2-Luc |
| Lung Cancer | A549-Luc, NCI-H82, NCI-H2171 | |
| Lymphoma | U937, NK92, Jeko-1, Daudi, Ramos, JVM-2, KAPPAS 299, Raj, SU-DHL-10, SU-DHL-16, U-2932, L-540 | Raji-Luc, U-937-Luc, MM.1S-Luc, Jeko-Luc, Thp-1-Luc, Daudi-Luc, Ramos |
| Melanoma | A375, COLO829, SK-MEL-28, SK-MEL-5 | A375-Luc |
| Multiple Myeloma | NCI-H929, MM.1R, MOLP-8, RPMI-8226, MM.1S | RPMI8226-Luc |
| Neuroblastoma | IMR-32, SK-N-BE(2) | |
| NSCLC | A549, HCC-827, NCI-H1703, NCI-H1755, NCI-H1975, NCI-H2122, NCI-H358, NCI-H460, NCI-H1299, NCI-H647 | |
| Osteosarcoma | MG63 | |
| Ovarian Cancer | OVCAR-3, SK-OV-3, TOV-112D | SKOV3-Luc, OVCAR-Luc |
| Pancreatic Cancer | AsPC-1, BxPC-3, CAPAN-1, CFPAC-1, HPAC, MIA PaCa-2, PANC-1, SW1990 | PANC-Luc |
| Plasmacytoma | U-266 | |
| Prostate Cancer | 22RV1, LNCaP, PC-3, LNCaP C4-2B | |
| Pulmonary Mucoepidermoid Carcinoma | NCI-H226, NCI-H292, NCI-H727, NCI-H69 | |
| Renal Carcinoma | ACHN, 786-O | |
| Sarcoma | HT1080, SJSA-1, U-2 OS | |
| SCLC | DMS-53, NCI-2171, NCI-H446, NCI-H526, NCI-H82, SHP-77 | |
| Skin Cancer | A431 | |
| Submandibular Adenosquamous Carcinoma | A253 | |
| Squamous Cell Carcinoma | FaDu | |
| Teratocarcinoma | PA-1 | |
| Tongue Squamous Cell Carcinoma | Cal 27 | |
| Uterine Cancer | HEC-1-A-Luc |