C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt
FAD4T|Strain NO.T053302
Transgenic (Tg)
- Product Type:
- Quantity: - +
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- Age:
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BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt |
| Strain Number: | T053302 |
| Official Symbol: | APP,PSEN1 |
| Strain Strategy: | T053302.FAD4T strain info.pdf |
| Official Full Name: | amyloid beta precursor protein,presenilin 1 |
| Also Known As: | AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN-II,PN2,alpha-sAPP,preA4 |
| NCBI Number: | 3515663 |
| Research Areas: | Disease Models,Neurodegenerative diseases,Alzheimer's disease |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Transgenic (Tg) |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer's Disease. Research (2023)2. H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFkappaB signaling pathway. J Neuroinflammation (2023)3. Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease. Pharmacol Res (2024)4. Mannose-Integrated Nanoparticle Hitchhike Glucose Transporter 1 Recycling to Overcome Various Barriers of Oral Delivery for Alzheimer's Disease Therapy. ACS Nano (2024)5. Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating alpha-Secretase. JOURNAL OF NEUROSCIENCE (2024)6. SIRT5-Mediated Desuccinylation of RAB7A Protects Against Cadmium-Induced Alzheimer's Disease-Like Pathology by Restoring Autophagic Flux. Advanced Science (2024)7. IL-17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease. J Cell Mol Med (2025) |